Spastin

An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.

Also Known As:

Spastic Paraplegia 4 Protein

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8727
        ATPases Associated with Diverse Cellular Activities: 169
        Spastin: 187
      - AAA Proteins: 25
        ATPases Associated with Diverse Cellular Activities: 169
        Spastin: 187
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - AAA Proteins: 25
      - ATPases Associated with Diverse Cellular Activities: 169
        Spastin: 187
  - Cytoskeletal Proteins: 743
    - Microtubule Proteins: 41
      - Microtubule-Associated Proteins: 3319
        Spastin: 187
  - Nerve Tissue Proteins: 3
    - Microtubule-Associated Proteins: 3319
      - Spastin: 187

H Søndergård Selected Research

H Søndergård Research Topics

Disease

Drug/Important Bio-Agent (IBA)